Assistant Professor Education: PhD, University of Konstanz, Germany (1994); Postdoctoral Fellow, Oregon State University (1994 - 99); Assistant Professor, Utrecht University, The Netherlands (1999 - 02) Email: claudia.maier@oregonstate.edu Office: 1047 ALS Phone: (541) 737-9533 FAX: (541) 737-2062 Mass Spectrometry Facility Website: http://mass-spec.science.oregonstate.edu

Our research emphasizes the analysis of proteins in relation to their function. Research efforts are directed towards the development and application of analytical protocols for the structural and functional characterization of proteins and their interaction with other biomolecules. As part of these efforts we focus on the use of mass spectrometric techniques and their combination with chemical approaches and modern (micro) separation techniques. Our research projects emphasize a) proteomics, i.e. the mass spectrometry-based characterization of proteins and peptides including their post-translational modifications and b) mass spectrometry-enabled conformational and non-covalent interaction studies of proteins and protein complexes using hydrogen/deuterium exchange approaches.

Representative Publications

• Design, Synthesis, and Application of a Hydrazide-Functionalized Isotope-Coded Affinity Tag for the Quantification of Oxylipid-Protein Conjugates, Anal. Chem., 2007, 79 (9), 3342-3354.
• New Role for an Old Probe: Affinity Labeling of Oxylipid Protein Conjugates by N'-Aminooxymethyl-carbonylhydrazino D-biotin, Anal. Chem. 2006, 78, 6847-6854.
• Pox proteomics: mass spectrometry analysis and identification of Vaccinia virion proteins, Virology Journal, 2006, 3, 1-16.
• Mass Tagging Approach for Mitochondrial Thiol Proteins, J. Proteome Res., 2005, 4 (4), 1403-1412.
• The Wewakpeptins, Cyclic Depsipeptides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya semiplena, J. Org. Chem., 2005, 70 (8), 3133-3139.
• Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry, Protein Science, 2002 11, 1738-1752.
• Intramolecular Interactions in Chemically Modified Escherichia coli Thioredoxin Monitored by Hydrogen/Deuterium Exchange and Electrospray Ionization Mass Spectrometry, Biochemistry, 2001, 40 (48), 14413-14421.
• Site-Specific Amide Hydrogen/Deuterium Exchange in E. coli Thioredoxins Measured by Electrospray Ionization Mass Spectrometry, J. Am. Chem. Soc., 2001, 123 (40), 9860-9866.